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PKBα/Akt Mouse, Unlabeled, Clone: 7, BD
Mouse Monoclonal Antibody
370.00 CHF - 679.00 CHF
Spezifikation
| Antigen | PKBα/Akt |
|---|---|
| Klon | 7 |
| Konzentration | 250μg/mL |
| Anwendungen | Western Blot |
| Klassifikation | Monoclonal |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
15815669
|
BD Biosciences
610836 |
50 μg |
370.00 CHF
1 Set |
Verfügbar ab: 23-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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|
15825669
|
BD Biosciences
610837 |
150 μg |
Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11. |
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Beschreibung
Rac (Related to the A and C kinases) protein kinase shows 73% and 68% to Protein Kinase C and PKA, respectively, and is also known as Protein Kinase B (PKB). It was also identified as the product of the v-akt oncogene from T-cell lymphomas. PKB mRNA is expressed in a wide variety of cell lines and has been detected in porcine brain, heart, liver, kidney, muscle, and ovary. Rac phosphorylates a number of physiological substrates including MBP, glycogen synthetase, PKA RII subunit, and histone H1. PKB is activated in response to growth factors through the activation of PI3-kinase and Ras. Activation of PI3-Kinase generates phosphatidylinositol 3,4-bisphosphate which may induce the membrane translocation of PKB coincident with its phosphorylation and activation. Cellular stress leading to the activation of the p38 MAP kinase also induces PKB activation, indicating a multiplicity of signaling pathways that activate PKB. Upon activation, PKB associates with some members of the PKC family of kinases, such as PKCδ and PKCζ. Downstream of PKB, GSK3 is thus far the only identified substrate for PKB phosphorylated in vivo.
Immunofluorescence, Immunoprecipitation, Western Blotting
Spezifikation
| PKBα/Akt | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified | |
| PKBα |
| 7 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Human, Mouse, Rat | |
| Human PKBα/Akt aa. 71-184 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.