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Phospho-TrkB (Tyr515) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA538076
Additional Details : Gewicht : 0.00900kg
Beschreibung
TrkB is a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). TrkB is involved in the development and maintece of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.Spezifikation
Phospho-TrkB (Tyr515) | |
Polyclonal | |
Unconjugated | |
NTRK2 | |
BDNF/NT-3 growth factors receptor precursor, EC 2.7.10.1, GP145-TrkB, GP145-TrkB/GP95-TrkB, NTRK2, Trk-B, TrkB tyrosine kinase, kinase TrkB | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
18212, 25054, 4915 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q16620, P15209, Q63604 | |
NTRK2 | |
A synthetic phosphopeptide derived from human Trk B around the phosphorylation site of Tyr515 (P-Q-YP-F-G) | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |