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Phospho-JIP1 (Thr103) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA538505
Additional Details : Gewicht : 0.00900kg
Beschreibung
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.Spezifikation
| Phospho-JIP1 (Thr103) | |
| Polyclonal | |
| Unconjugated | |
| MAPK8IP1 | |
| IB1, JIP-1, JIP1, PRKM8IP, C-Jun-amino-terminal kinase-interacting protein 1, IB-1, JNK MAP kinase scaffold protein 1, JNK-interacting protein 1, PRKM8 interacting protein, islet-brain 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 116457, 19099, 9479 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunofluorescence, Western Blot | |
| 1 mg/mL | |
| Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q9UQF2, Q9WVI9, Q9R237 | |
| MAPK8IP1 | |
| A synthetic phosphopeptide derived from human JIP1around the phosphorylation site of Thr103 (G-D-TP-P-G) | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |