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Phospho-AMPK alpha-1,2 (Thr183, Thr172) Rabbit anti-Human, Mouse, Polyclonal, Invitrogen

Rabbit Polyclonal Antibody

Marke:  Invitrogen 441150G

Additional Details : Gewicht : 0.10000kg

Artikelnummer. 10662384

  • 463.00 CHF / 1 Stück


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Beschreibung

Beschreibung

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Spezifikation

Spezifikation

Phospho-AMPK alpha-1,2 (Thr183, Thr172)
Polyclonal
Dulbecco′s PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide; pH 7.3
P54646, Q13131, Q5EG47, Q8BRK8
AMPK, AMPKa1, 5′-AMP-activated protein kinase catalytic subunit alpha-1, 5′-AMP-activated protein kinase, catalytic alpha-1 chain, AMP -activate kinase alpha 1 subunit, AMP-activated protein kinase, catalytic, alpha-1, AMPK alpha 1, AMPK subunit alpha-1, tau-protein kinase PRKAA1, PRKAA2, protein kinase, AMP-activated, alpha 2 catalytic subunit, AMPK, AMPK2, PRKAA, 5′-AMP-activated protein kinase, catalytic alpha-2 chain, AMP-activated protein kinase alpha 2 catalytic subunit, AMPK-alpha-2 chain, pAMPK
Rabbit
IgG
100 μL
-20°C
Primary
105787, 108079, 5562, 5563
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
PRKAA1
Liquid
PRKAA1, Prkaa2
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human AMPK alpha 1 that contains threonine 183 and AMPK alpha 2 that contains threonine 172. The sequence is conserved in human, mouse and rat.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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