missing translation for 'onlineSavingsMsg'
Learn More

NBS1 Mouse, Unlabeled, Clone: 34, BD

Mouse Monoclonal Antibody

563.39 CHF

Spezifikation

Antigen NBS1
Klon 34
Konzentration 250μg/mL
Anwendungen Western Blot
Klassifikation Monoclonal
Mehr Spezifikationen ansehen

Produkte 1
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15836049
Unterlagen ansehen Aktionsdetails
BD Biosciences
611871
150 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
N/A Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Beschreibung

Beschreibung

Nijmegen Breakage Syndrome (NBS) is characterized by extreme radiation sensitivity and chromosomal instability. The NBS1 gene product, p95/nibrin/NBS1, forms a complex with Rad50 and Mre11. Cells deficient in this complex have problems with DNA double-strand break repair, cell cycle checkpoint control, and telomere length maintenance. NBS1 contains a forkhead-associated domain (FHA) and a breast cancer carboxy-terminal domain (BRCT) in the N-terminal region. Both of these domains have been found in DNA-damage responsive cell cycle checkpoint proteins. The complex containing NBS1, Rad50, and Mre11 possesses manganese-dependent single stranded DNA endonuclease and 3′ to 5′ exonuclease activities. In addition, NBS1 is required for DNA-damage dependent phosphorylation of Mre11. This phosphorylation may be required for proper nuclear localization of the NBS1-Rad50-Mre11 complex to sites of DNA double-strand breaks. NBS1 interacts directly with telomere repeat binding factor, TRF1, via its C-terminal region, and both NBS1 and Mre11 co-localize with TRF1 at promyelocytic leukemia nuclear bodies. Thus, the NBS1-Rad50-Mre11 complex may be important for both DNA damage repair, and telomere length maintenance.

Host Species: Mouse
Clone: 34
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human NBS1 aa. 620-732

Immunofluorescence, Western Blotting

Spezifikation

Spezifikation

NBS1
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
Nijmegen Breakage Syndrome-1
34
Western Blot
Unconjugated
RUO
Canine, Chicken, Human, Mouse, Rat
Human NBS1 aa. 620-732
Primary
Store undiluted at -20°C.
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications

For Research Use Only.