CD54 Hamster anti-Mouse, FITC, Clone: 3E2, BD
Hamster Monoclonal Antibody
Marke: BD Biosciences 561898
Additional Details : Gewicht : 0.01000kg
The 3E2 antibody reacts with CD54 (ICAM-1), a 95-kDa member of the Ig superfamily found on lymphocytes, vascular endothelium, high endothelial venules, epithelial cells, macrophages, and dendritic cells. ICAM-1 is a ligand for LFA1 (CD11a/CD18) and Mac-1 (CD11b/CD18). Its expression is upregulated upon stimulation by inflammatory mediators such as cytokines and LPS. Studies with mouse Icam1-transfected antigen-presenting cells, with CD54-blocking antibodies, and in CD54-deficient mice indicate that CD54 participates in inflammatory reactions and antigen-specific immune responses. In addition, there is evidence that CD54 is a receptor involved in MHC-non-restricted responses to weakly immunogenic tumor cells. The 3E2 antibody has been reported to block in vitro and in vivo intracellular adhesion events involved in immune responses.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|ICAM-1; Icam1; Intercellular adhesion molecule 1; Ly-47; MALA-2; MyD10|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
For Research Use Only.