missing translation for 'onlineSavingsMsg'
Learn More

Karyopherin α Mouse, Unlabeled, Clone: 2, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 610486

Additional Details : Gewicht : 0.01000kg

 Lernen Sie weitere Varianten dieses

Artikelnummer. 15825489

  • auf Anfrage / 1 Set

Dieser Artikel kann nicht online bestellt werden, da Preisänderungen vorbehalten sind. Bitte kontaktieren Sie unser Produktsupport-Team unter 056 618 41 11 für weitere Informationen.


Beschreibung

Beschreibung

The two step process of importing proteins into the nucleus involves the binding and interaction of several cytosolic and nuclear pore proteins. Proteins to be translocated into the nucleus contain a nuclear localization sequence (NLS) which is recognized and bound by carrier proteins in the cytosol. Heterodimers belonging to a highly conserved family of proteins called karyopherins are required for successful nuclear localization of cytosolic proteins. The α-subunits appear to function in the binding of NLS (both simple and bitartite NLS motifs), but both α- and β-subunits are required for successful docking to the nuclear envelope. ATP is required for complete translocation of proteins into the nucleus. Karyopherin α2 was first identified as Rch-1, an NLS receptor which interacts with the RAG-1 recombination-activating protein in developing B and T cells. Rch-1 has been reported to be 44% identical to karyopherin α1 (hSRP-1 /NPI-1).

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

Karyopherin α
2
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Rch-1
Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
150μg
Cell Biology
Primary
Canine, Drosophila, Human, Murine, Rat
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.