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JNK1 with control Mouse anti-Human, Unlabeled, Clone: G151-333, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 551196

Additional Details : Gewicht : 0.02000kg

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Artikelnummer. 15826568

  • 280.00 CHF / 1 Stück


Verfügbar ab
01-06-2021
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Beschreibung

Beschreibung

C-Jun NH2-terminal kinase (JNK1) binds to the c-Jun terminal transactivation domain and phosphorylates it on Ser-63 and Ser-73. Phosphorylation enhances the transcriptional activity of c-Jun. The Ser-Pro-acidic sequence targeted by JNK1 kinase activity establishes it as a proline-directed kinase related to the MAP kinases and cyclin dependent kinases. JNK1 migrates with an apparent molecular weight of 46 kDa by SDS-PAGE. A related protein of 55 kDa has similar kinase activity. JNK1 may act as a tumor promoter in response to UV-irradiation since its activity is potently stimulated by such radiation. This has relevance to the observations that c-Jun transcriptional activity is upregulated by UV irradiation. The G151-333 antibody recognizes both the 46 kDa JNK1 and a related ∽55 kDa protein (which may be a modified form of JNK1). It does not cross-react with JNK2. G151-333 precipitates an active kinase. A bacterially expressed fusion protein of human JNK1 was used as immunogen.

Spezifikation

Spezifikation

JNK1 with control
G151-333
Affinity Purified
IgG1
RUO
Primary
Purified Mouse Anti-Human JNK1 (50μg); HeLa Control Lysate (50μg)
Western Blot
Unconjugated
Murine
50μg
Store undiluted at -20°C.
Monoclonal
Human
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.