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JNK1 with control Mouse anti-Human, Unlabeled, Clone: G151-333, BD

Mouse Monoclonal Antibody

574.00 CHF

Spezifikation

Antigen JNK1 with control
Klon G151-333
Anwendungen Western Blot
Klassifikation Monoclonal
Konjugat Unconjugated
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Produkte 1
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15836568
Unterlagen ansehen Aktionsdetails
BD Biosciences
551197
150 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
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Beschreibung

Beschreibung

C-Jun NH2-terminal kinase (JNK1) binds to the c-Jun terminal transactivation domain and phosphorylates it on Ser-63 and Ser-73. Phosphorylation enhances the transcriptional activity of c-Jun. The Ser-Pro-acidic sequence targeted by JNK1 kinase activity establishes it as a proline-directed kinase related to the MAP kinases and cyclin dependent kinases. JNK1 migrates with an apparent molecular weight of 46 kDa by SDS-PAGE. A related protein of 55 kDa has similar kinase activity. JNK1 may act as a tumor promoter in response to UV-irradiation since its activity is potently stimulated by such radiation. This has relevance to the observations that c-Jun transcriptional activity is upregulated by UV irradiation. The G151-333 antibody recognizes both the 46 kDa JNK1 and a related ∽55 kDa protein (which may be a modified form of JNK1). It does not cross-react with JNK2. G151-333 precipitates an active kinase. A bacterially expressed fusion protein of human JNK1 was used as immunogen.

Spezifikation

Spezifikation

JNK1 with control
Western Blot
Unconjugated
RUO
IgG1
Affinity Purified
G151-333
Monoclonal
Mouse
Human
Primary
Store undiluted at -20°C.
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