missing translation for 'onlineSavingsMsg'
Learn More

Itch Mouse, Unlabeled, Clone: 32, BD

Mouse Monoclonal Antibody

414.00 CHF - 610.00 CHF

Spezifikation

Antigen Itch
Klon 32
Konzentration 250μg/mL
Anwendungen Western Blot
Klassifikation Monoclonal
Mehr Spezifikationen ansehen

Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15815839
Unterlagen ansehen Aktionsdetails
BD Biosciences
611198
50 μg
414.00 CHF
1 Set
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 23-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
15825839
Unterlagen ansehen Aktionsdetails
BD Biosciences
611199
150 μg
610.00 CHF
1 Set
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 23-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

Maintenance of cellular function requires timely and selective degradation of key regulatory proteins. For example, progression of the mammalian cell cycle is regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins via the ubiquitin pathway. Ubiquitin, a soluble protein of 76 amino acids, is enzymatically attached to an ε-NH2-Lys in a target protein. Ubiquitin-conjugated proteins are recognized and degraded by the 26S proteasome. Ubiquitination requires ubiquitin-activating enzyme E1, ubiquitin-conjugating enzymes E2, and ubiquitin ligases E3. The direction of ubiquitin transfer is from E1 to E2 and from E2 to E3. Itch, a novel E3 ubiquitin ligase, is absent in the Non-agouti-lethal 18H mice. These mice develop immunological, inflammatory, epithelial, and hematopoietic diseases. Itch contains four WW protein interaction domains, which bind to proline-rich sequences in a fashion similar to SH3 domains. In addition, Itch contains a C-terminal Hect domain, which is conserved in the E3 family of ubiquitin ligases. Thus, Itch is important in the ubiquitin-dependent protein degradation occurring in normal hematopoiesis and inflammation.

Host Species: Mouse
Clone: 32
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse Itch aa. 114-220
Formula Weight [Chemical]: 113kDa

Immunofluorescence, Western Blotting

Spezifikation

Spezifikation

Itch
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
32
Western Blot
Unconjugated
RUO
Human, Mouse, Rabbit, Rat
Mouse Itch aa. 114-220
Primary
Store undiluted at -20°C.
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications

For Research Use Only.