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IRS-1 Mouse, Unlabeled, Clone: 6, BD
Mouse Monoclonal Antibody
361.00 CHF - 730.00 CHF
Spezifikation
| Antigen | IRS-1 |
|---|---|
| Klon | 6 |
| Konzentration | 250μg/mL |
| Anwendungen | Western Blot |
| Klassifikation | Monoclonal |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
15815919
|
BD Biosciences
611394 |
50 μg |
361.00 CHF
1 Stück |
Verfügbar ab: 17-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
|||||
|
15825919
|
BD Biosciences
611395 |
150 μg |
730.00 CHF
1 Stück |
Verfügbar ab: 22-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
|||||
Beschreibung
The IRS (Insulin receptor substrate) proteins IRS-1, IRS-2, IRS-3, and IRS-4 are major substrates of the insulin receptor tyrosine kinase and the insulin-like growth factor-1 receptor. IRS proteins contain an N-terminal pleckstrin homology (PH) domain, an ATP-binding domain, and multiple tyrosine phosphorylation sites in the C-terminus. Following insulin receptor ligation, IRS-1 binds to the juxtamembrane region of the receptor and is tyrosine phosphorylated. This facilitates its interaction with SH2 domain-containing signaling proteins, such as PI3 kinase, fyn, Grb2, and PTP1D. Phosphorylation dramatically reduces the affinity of IRS-1 for the insulin receptor, indicating that dissociation from the receptor and subsequent subcellular translocation are important to IRS-1 function in the pleiotropic effects induced by insulin. In support of this, IRS-1-null mice are viable, but exhibit growth retardation and abnormal glucose metabolism. In cases of reduced IRS-1 expression, certain IRS-1 functions can be assumed by the related IRS-2 protein, while other activities linked to IRS-1 are inhibited. Thus, IRS-1 is an essential component of insulin induced signal transduction.
Immunofluorescence, Western Blotting
Spezifikation
| IRS-1 | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 6 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Mouse, Rat | |
| Rat IRS-1 aa. 1131-1234 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.