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IL-17F Mouse anti-Mouse, Alexa Fluor 647, Clone: O79-289, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 561630

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15821189

  • 413.00 CHF / 1 Stück


Verfügbar ab
28-05-2021
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Beschreibung

Beschreibung

The O79-289 monoclonal antibody specifically binds to the inflammatory cytokine protein, Interleukin-17 (IL-17F). IL-17F is a member of the IL-17 family of cytokines. Among IL-17 family members, IL-17F has the highest amino acid sequence homology to IL-17A. IL-17F is produced by activated CD4+ T helper (Th17) cells, CD8+ T (Tc17) cells and γδ T cells. IL-17F can be secreted as homodimers or as heterodimers with IL-17A. IL-17F and IL-17A have overlapping functions such as inducing epithelial cells and fibroblasts to produce proinflammatory cytokines and chemokines including IL-6, GM-CSF, CXCL1, CCL2, and CCL7. These factors attract and activate neutrophils and other cell types that mediate protective responses against pathogenic microbes or pathologic allergic or autoimmune diseases. IL-17 gene knockout studies have shown that IL-17F and IL-17A have independent functions as well. IL-17F and IL-17A exert their biological function by binding to and signaling through IL-17 receptors comprised of the transmembrane receptor subunits, IL-17RA (CD217) and IL-17RC.

Spezifikation

Spezifikation

IL-17F
O79-289
Alexa Fluor 647
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
Il17f; interleukin 17F; Interleukin-17F
Affinity Purified
Mouse IL-17F Recombinant Protein
0.1mg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.