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CD19 Mouse anti-Human, Brilliant Violet 605, Clone: SJ25C1, BD
Mouse Monoclonal Antibody
350.00 CHF - 750.00 CHF
Spezifikation
Antigen | CD19 |
---|---|
Klon | SJ25C1 |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Konjugat | Brilliant Violet 605 |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15822119
|
BD Biosciences
562654 |
25 Tests |
350.00 CHF
1 Stück |
Verfügbar ab: 14-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15812119
|
BD Biosciences
562653 |
100 Tests |
750.00 CHF
1 Stück |
Verfügbar ab: 03-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
|||||
Beschreibung
The SJ25C1 monoclonal antibody specifically binds to CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 90-kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation.
This antibody is conjugated to BD Horizon BV605 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407-nm and Em Max of 602-nm, BD Horizon BV605 can be excited by a violet laser and detected with a standard 610/20-nm filter set. BD Horizon BV605 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an Em max at 605-nm. Due to the excitation of the acceptor dye by the green (532 nm) and yellow-green (561 nm) lasers, there will be significant spillover into the PE and BD Horizon PE-CF594 detectors off the green or yellow-green lasers. BD Horizon BV605 conjugates are very bright, often exhibiting brightness equivalent to PE conjugates and can be used as a third color off of the violet laser.
Spezifikation
CD19 | |
Flow Cytometry | |
Brilliant Violet 605 | |
RUO | |
Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
IgG1 κ | |
Affinity Purified | |
B4; B-lymphocyte antigen CD19; Leu-12 |
SJ25C1 | |
Monoclonal | |
Mouse | |
Human | |
Human NALM1 + NALM16 cells | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.