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GSK-3b (pY216) Mouse, Unlabeled, Clone: 13A, BD

Mouse Monoclonal Antibody

510.00 CHF - 645.00 CHF

Spezifikation

Antigen GSK-3b (pY216)
Klon 13A
Konzentration 250μg/mL
Anwendungen Western Blot
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15826169
Unterlagen ansehen Aktionsdetails
BD Biosciences
612312
50 μg
510.00 CHF
1 Stück
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Verfügbar ab: 23-04-2024
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15836169
Unterlagen ansehen Aktionsdetails
BD Biosciences
612313
150 μg
645.00 CHF
1 Stück
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 23-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

Glycogen Synthase Kinase-3β (GSK-3β) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. GSK-3β is identical to the Tau Protein Kinase I (TPK I) that plays a role in the formation of the histopathological brain lesions of Alzheimer's disease (AD). Phosphorylation of the cytoskeletal protein, tau, by GSK-3β converts these proteins into paired helical filaments (PHF) which are found in the neurofibrillary tangles and degenerative neurites of AD patients. Regulation of GSK-3β activity through both serine and tyrosine phosphoylation is a critical determinant of cell death or survival. Factors that promote cell survival, such as growth factors, activate Akt which, in turn phosphorylates GSK-3β at Ser-9, leading to inactivation of its kinase activity. On the contrary, events that promote cell death, such as growth factor removal, cause increases in phosphorylation within the catalytic domain at Tyr-216 and stimulate kinase activity. Thus GSK-3β is a tightly regulated death promoting kinase that regulates the activity of various proteins, including cytokeletal and enzymatic proteins.

Western Blotting

Spezifikation

Spezifikation

GSK-3b (pY216)
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
13A
Western Blot
Unconjugated
RUO
Human, Mouse, Rat
Rat GSK-3β (pY216) Peptide
Primary
Store undiluted at -20°C.
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Dokumentation

Product Certifications

For Research Use Only.