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Granzyme B Mouse anti-Human, Alexa Fluor 647, Clone: GB11, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 561999

Additional Details : Gewicht : 0.00840kg

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Artikelnummer. 15831549

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Beschreibung

Beschreibung

The GB11 antibody specifically reacts with human granzyme B, a serine protease of approximately 32 kDa. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes. Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis. Granzyme B may also be involved in the hydrolysis of extracellular matrix components. Detectable levels of granzyme B have been detected in sera from healthy volunteers. The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.

Spezifikation

Spezifikation

Granzyme B
GB11
Alexa Fluor 647
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Primary
Human
Flow Cytometry
0.2mg/mL
GZMB; Granzyme-2; CCPI; CGL1; CSPB; CTLA1; CTSGL1; GRB; HLP; SECT
Affinity Purified
Human Granzyme B
25μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.