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Gαq Mouse, Unlabeled, Clone: 10, BD
Mouse Monoclonal Antibody
375.00 CHF - 547.01 CHF
Spezifikation
| Antigen | Gαq |
|---|---|
| Klon | 10 |
| Konzentration | 250μg/mL |
| Anwendungen | Western Blot |
| Klassifikation | Monoclonal |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
15816269
|
BD Biosciences
612704 |
50 μg |
375.00 CHF
1 Stück |
Verfügbar ab: 16-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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|
15826269
|
BD Biosciences
612705 |
150 μg |
Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11. |
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Beschreibung
The GTP binding regulatory proteins (G proteins) consist of three subunits: α, β, and γ. These heterotrimeric proteins function at membranes to relay signals from cell surface receptors to intracellular effectors. The α subunit is unique for each G protein and contains the site of GTP binding and hydrolysis, as well sites for receptor and effector interactions. The βγ subunit complex interacts directly with receptors and the α subunit. The Gα family includes four families: the Gαs family including Gαs , Gαo1f, and Gαt, the Gαi family including Gαi, Gαo, and Gαz, the Gαq/Gα11 family and the Gα12/13 family. The Gαq protein is 88% homologus with Gα11 and both are widely expressed. These G proteins activate phospholipase C proteins, which induce calcium signaling events. G protein coupled receptors (GPCRs) involved in regulating Wnt signaling activate Gαq, phospholipase Cβ, and induce calcium-dependent activation of calpain. These events promote β-catenin nuclear export and proteolysis. Gαq has also been implicated in metabotropic glutamate receptor signaling. Thus, Gαq isoforms activate phospholipase C proteins in various G-protein coupled receptor pathways.
Immunofluorescence, Western Blotting
Spezifikation
| Gαq | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 10 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Chicken, Human, Mouse, Rat | |
| Human Gαq aa. 22-31 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.