missing translation for 'onlineSavingsMsg'
Learn More
Learn More
FoxP3 Mouse anti-Human, PE, Clone: 259D/C7, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 560082
Additional Details : Gewicht : 0.01000kg
Beschreibung
The 259D/C7 antibody reacts with the human FoxP3 transcription factor, a member of the forkhead or winged helix family of transcription factors. The expression of FoxP3, also known as Scurfin, IPEX and JM2, has been found to be associated with CD4+ regulatory T cells and represents a specific marker for these cells. Flow-cytometric analysis has shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of CD4+CD25int cell population are FoxP3 positive. Approximately 5-10% of peripheral CD4+ cells are CD4+CD25+ T regulatory cells. T regulatory cells are thought to play a critical role in the control of T cell mediated autoimmunity by suppressing the proliferation and cytokine production of other T cells. To support this hypothesis, it has been found that FOXP3 is mutated in scurfy (sf) mice. The 259D/C7 antibody reacts with all currently identified isoforms of human FoxP3 and is cross-reactive with Cynomolgus, Rhesus and Baboon.
Spezifikation
| FoxP3 | |
| Monoclonal | |
| PE | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| FoxP3 recombinant protein | |
| 25 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| 259D/C7 | |
| Scurfin, IPEX, JM2 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Baboon, Cynomolgus, Human, Rhesus Monkey | |
| IgG1 |
For Research Use Only.