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FoxP3 Mouse anti-Human, PE, Clone: 259D/C7, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 560082

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15829918

  • 283.00 CHF / 1 Stück


Verfügbar ab
03-06-2021
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

The 259D/C7 antibody reacts with the human FoxP3 transcription factor, a member of the forkhead or winged helix family of transcription factors. The expression of FoxP3, also known as Scurfin, IPEX and JM2, has been found to be associated with CD4+ regulatory T cells and represents a specific marker for these cells. Flow-cytometric analysis has shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of CD4+CD25int cell population are FoxP3 positive. Approximately 5-10% of peripheral CD4+ cells are CD4+CD25+ T regulatory cells. T regulatory cells are thought to play a critical role in the control of T cell mediated autoimmunity by suppressing the proliferation and cytokine production of other T cells. To support this hypothesis, it has been found that FOXP3 is mutated in scurfy (sf) mice. The 259D/C7 antibody reacts with all currently identified isoforms of human FoxP3 and is cross-reactive with Cynomolgus, Rhesus and Baboon.

Spezifikation

Spezifikation

FoxP3
259D/C7
Scurfin, IPEX, JM2
Affinity Purified
FoxP3 recombinant protein
25 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
PE
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG1
RUO
Primary
Baboon, Cynomolgus, Human, Rhesus
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.