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FoxP3 Mouse anti-Human, Alexa Fluor 647, Clone: 259D/C7, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 560045

Additional Details : Gewicht : 0.02000kg

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Artikelnummer. 15829888

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The 259D/C7 antibody reacts with the human FoxP3 transcription factor, a member of the forkhead or winged helix family of transcription factors. The expression of FoxP3, also known as Scurfin, IPEX and JM2, has been found to be associated with CD4+ regulatory T cells and represents a specific marker for these cells. Flow-cytometric analysis has shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of CD4+CD25int cell population are FoxP3 positive. Approximately 5-10% of peripheral CD4+ cells are CD4+CD25+ T regulatory cells. T regulatory cells are thought to play a critical role in the control of T cell mediated autoimmunity by suppressing the proliferation and cytokine production of other T cells. To support this hypothesis, it has been found that FOXP3 is mutated in scurfy (sf) mice. The 259D/C7 antibody reacts with all currently identified isoforms of human FoxP3 and is cross-reactive with Cynomolgus, Rhesus and Baboon. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated to Alexa Fluor™ 647 under optimum conditions, and unreacted Alexa Fluor™ 647 was removed.

Host Species: Mouse
Clone: 259D/C7
Isotype: Mouse IgG1
Species Reactivity: Human
Immunogen: FoxP3 recombinant protein

Intracellular Staining



Scurfin, IPEX, JM2
Affinity Purified
FoxP3 recombinant protein
100 Tests
Baboon, Cynomolgus, Human, Rhesus
Flow Cytometry
Alexa Fluor 647
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Sicherheitsdatenblatt (SDS)

For Research Use Only.