missing translation for 'onlineSavingsMsg'
Learn More

DLC-1 Mouse anti-Human, Unlabeled, Clone: 3, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 612021

Additional Details : Gewicht : 0.01000kg

 Lernen Sie weitere Varianten dieses

Artikelnummer. 15826079

  • auf Anfrage / 1 Set

Dieser Artikel kann nicht online bestellt werden, da Preisänderungen vorbehalten sind. Bitte kontaktieren Sie unser Produktsupport-Team unter 056 618 41 11 für weitere Informationen.


Beschreibung

Beschreibung

Members of the Ras superfamily of GTPases are distantly related to the heterotrimeric G proteins and shuttle between inactive and active GTP-bound forms. Conversion between these forms is controlled by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Rho is a GTPase that regulates cell morphology and motility in response to extracellular signals. p190A, p190B, and p122 RhoGAPs all contain RhoGAP domains and regulate the GTPase activity of Rho. p122 RhoGAP exhibits GAP activity for RhoA, but not Rac1, and binds and activates PLC-δ1. Microinjection of p122 RhoGAP suppresses LPA-induced formation of stress fibers and focal adhesions. Deleted in liver cancer-1 (DLC-1) was identified by its frequent deletion in liver cancer and is a human homologue of rat p122 RhoGAP. DLC-1 is expressed in many hepatocellular carcinoma tissues and cell lines and could be an important tumor suppressor gene. In normal human tissues, DLC-1 is expressed widely with the highest expression in heart and lung. Both p122 RhoGAP and DLC-1 have RhoGAP domains toward their C-terminal regions, which is thought to be important for regulation of Rho GTPase activity in many tissues.

Host Species: Mouse
Clone: 3
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human DLC-1 aa. 47-249

Immunofluorescence, Western Blotting

Spezifikation

Spezifikation

DLC-1
3
Unconjugated
Affinity Purified
Human DLC-1 aa. 47-249
150μg
Cell Biology
Primary
Human
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.