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Cyclin D1 Mouse anti-Human, Unlabeled, Clone: G124-326, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 554180

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15827608

  • 282.00 CHF / 1 Stück


Verfügbar ab
08-06-2021
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Beschreibung

Beschreibung

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins contain a conserved amino acid sequence motif, the cyclin box, which allows their binding to cdks to form active complexes that regulate the progression of the cell cycle. The synthesis and degradation of cyclins is tightly controlled in a cell cycle specific manner. Several classes of cyclins (A-E) have been described. Cyclins have been placed into functional groups as follows: Group 1 (cyclins A, B, D1, D2, D3, E and F) functions primarily in cell cycle reguation; Group 2 (cyclins C and H) also plays a role in transcriptional regulation; Group 3 (cyclins G1, G2 and I) may play a role distinct from other cyclins. Specific substrates for cyclin-cdk complexes include nuclear lamins, histones, oncogenes (c-src, c-abl, SV40 large-T Ag), tumor suppressor genes (Rb and p53), and others. The D-type cyclins are involved in regulating the passage of mammalian cells through G1. The reduced molecular weights of cyclin D1 is ∽36kda. G124-326 recognizes human cyclin D1 and cross-reacts with the mouse homolog (Cyl1) of human cyclin D1. It does not cross-react with human cyclins D2 and D3. Recombinant full-length human cyclin D1 was used as immunogen.

Host Species: Mouse
Clone: G124-326
Isotype: IgG1
Species Reactivity: Human
Immunogen: Recombinant full-length human cyclin D1
Formula Weight [Chemical]: 36kDa

Flow Cytometry, Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

Cyclin D1
G124-326
Unconjugated
Affinity Purified
Recombinant full-length human cyclin D1
0.1mg
Cell Biology
Primary
Human, Murine
Western Blot
0.5mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at 4°C
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.