Learn More
CD8 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA516693
Additional Details : Gewicht : 0.01000kg
Beschreibung
PA5-16693 targets CD8 in IHC (P) applications and shows reactivity with Human samples. The PA5-16693 immunogen is synthetic peptide sequence comprising the 13 C-terminal amino acids of the cytoplasmic domain of alpha chain of the CD8 molecule.
CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).Spezifikation
CD8 | |
Polyclonal | |
PBS with 1% BSA and 0.1% sodium azide | |
P10966, P33706, P01732 | |
CD8A, CD8B | |
Synthetic peptide sequence comprising the 13 C-terminal amino acids of the cytoplasmic domain of alpha chain of the CD8 molecule | |
500 μL | |
Primary | |
Canine, Human, Rhesus Monkey | |
Antibody | |
IgG |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
Unconjugated | |
CD8B | |
CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta | |
Rabbit | |
Affinity chromatography | |
RUO | |
403157, 926, 925 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |