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CD3 Mouse anti-Human, BUV395, Clone: UCHT1, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 563548
Additional Details : Gewicht : 0.01000kg
Beschreibung
The UCHT1 monoclonal antibody specifically binds to the human CD3 ε -chain, a 20-kDa subunit of the CD3/T cell antigen receptor complex. CD3 ε is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes. Studies from the HLDA Workshop show that this antibody is mitogenic for CD3 ε -positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-CD28 antibody. CD3 plays a central role in signal transduction during antigen recognition. The UCHT1 antibody stains both surface and intracellular CD3 ε unlike the other CD3 clone, HIT3a, that stains only extracellular CD3 ε .
The antibody was conjugated to BD Horizon™ BUV395 which has been exclusively developed by BD Biosciences as an optimal dye for use on a 355nm laser equipped instrument. With an Ex Max at 348nm and an Em Max at 395nm, this dye has virtually no spillover into any other detector. BD Horizon™ BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.
Spezifikation
| CD3 | |
| Monoclonal | |
| Brilliant Ultraviolet 395 | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human infant thymocytes and peripheral blood lymphocytes from a Sezary Syndrome donor | |
| 25 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| UCHT1 | |
| CD3e; CD3E; T3E; TCRE; T-cell surface antigen T3/Leu-4 epsilon | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human | |
| IgG1 κ |
For Research Use Only.