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CD3ε Hamster anti-Mouse, Biotin, Clone: 145-2C11, BD

Hamster Monoclonal Antibody

406.00 CHF - 630.00 CHF

Spezifikation

Antigen CD3 ε
Klon 145-2C11
Konzentration 0.5mg/mL
Anwendungen Flow Cytometry
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15826968
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BD Biosciences
553059
0.1 mg
406.00 CHF
1 Stück
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Verfügbar ab: 23-04-2024
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15836968
Unterlagen ansehen Aktionsdetails
BD Biosciences
553060
0.5 mg
630.00 CHF
1 Stück
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 16-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

The 145-2C11 antibody reacts with the 25-kDa ε chain of the T-cell receptor-associated CD3 complex, which is expressed on thymocytes, mature T lymphocytes, and NK-T cells. The cytoplasmic domain of CD3e participates in the signal transduction events which activate several cellular biochemical pathways as a result of antigen recognition. Soluble 145-2C11 antibody can activate either unprimed (naive) or primed (memory/preactivated) T cells in vivo or in vitro, in the presence of Fc receptor-bearing accessory cells. In contrast, plate-bound 145-2C11 can activate T cells in the absence of accessory cells. Soluble 145-2C11 antibody has been reported to induce re-directed lysis of Fc receptor-bearing target cells by CTL clones and can also block lysis of specific target cells by antigen-specific CTL's. Under some conditions, T-cell activation by 145-2C11 antibody has been reported to result in apoptotic cell death. The 145-2C11 antibody does not cross-react with rat leukocytes and it has been reported that pre-incubation of thymus cell suspensions at 37°C for 2-4 hours prior to staining enhances the ability of anti-CD3ε and anti-αβ TCR mAbs to detect the T-cell receptor on immature thymocytes. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Hamster
Clone: 145-2C11
Isotype: IgG1 κ
Species Reactivity: Mouse
Immunogen: H-2Kb specific cytotoxic T lymphocyte clone BM10-37

Flow Cytometry

Spezifikation

Spezifikation

CD3 ε
0.5mg/mL
Monoclonal
Hamster
Immunology
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG1 κ
Affinity Purified
CD3; CD3 epsilon; Cd3e; CD3ε; T3e
145-2C11
Flow Cytometry
Biotin
RUO
Mouse
H-2Kb specific cytotoxic T lymphocyte clone BM10-37
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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For Research Use Only.