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CD271 Mouse anti-Human, PE, Clone: C40-1457, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 557196

Additional Details : Gewicht : 0.02000kg

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Artikelnummer. 15818858

  • 386.00 CHF / 1 Stück


Verfügbar ab
03-06-2021
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

The C40-1457 monoclonal antibody specifically binds to CD271, the nerve growth factor receptor (NGFR). CD271 is a transmembrane 75 kDa protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves. It is also expressed by cells in some epithelial, mesenchymal and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), apolypeptide that is essential for normal development of the nervous system. NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of peripheral neurons. NGF binds to two distinctive surface receptors expressed by target cells, the p140-TrkA (NTRK1) and the p75 NGFR. High affinity binding of NGF requires that both receptor molecules be expressed. NGFR has been found on human and rat lymphocytes. A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers of reactive lymph nodes were found to express CD271. It has been reported that NGFR interaction with its ligand, NGF, may play a role in immunoregulation. NGF may function as a B-cell growth factor.

Spezifikation

Spezifikation

CD271
C40-1457
NGFR; NTR; p75NTR; p75 ICD; TNFRSF16; TNR16; LNGFR
Affinity Purified
IgG1, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
PE
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
100 Tests
Immunology
Primary
Human
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.