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CD244.2 Mouse anti-Mouse, FITC, Clone: 2B4, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 553305

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15817138

  • 525.00 CHF / 1 Stück


Verfügbar ab
08-06-2021
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Beschreibung

Beschreibung

CD244 is a type I transmembrane glycoprotein that is also known as Natural killer cell receptor 2B4 (NKR2B4), or Signaling lymphocytic activation molecule 4 (SLAMF4). CD244 is a member of the CD2 subset of the immunoglobulin superfamily (CD2 IgSF). It is expressed on all natural killer (NK) cells, IL-2-activated NK (LAK) cells, committed progenitors of NK cells, and a subset of T lymphocytes which mediate non-MHC-restricted cytoxicity, including dendritic epidermal T cells. The 2B4 monoclonal antibody specifically binds to CD244.2, the 2B4 alloantigen which is expressed on C57BL/6 and C58/J mice, but not in most strains tested (A/J, AKR, BALB/c, CBA/J, CBA/N, C3H/He, C57BR, DBA/1, DBA/2, NZB, SJL/J, 129). At least two isoforms of CD244.2 protein, products of alternative splicing of hnRNA, are expressed on IL-2-activated C57BL/6 NK cells. They differ only in their cytoplasmic domains; with 2B4L (150-aa cytoplasmic tail) having inhibitory activity and 2B4S (93-aa tail) being stimulatory. The extracellular domain of CD244 is a ligand for another CD2 IgSF member, CD48. 2B4 antibody activates lytic and secretory functions of IL-2-cultured NK cells and CD244.2+ T cells.

Spezifikation

Spezifikation

CD244.2
2B4
FITC
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Murine
IgG2b, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
CD242.2; 2B4 B6 Alloantigen; Ly90; NAIL; Nmrk; SLAMF4
Affinity Purified
rIL-2-propagated NK1.1+ cells from C57BL/6 mice
0.5mg
Immunology
Primary
Murine
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.