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CD195 Mouse anti-Human, PE-Cy7, Clone: 2D7/CCR5, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 557752

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15819038

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Beschreibung

Beschreibung

The 2D7/CCR5 monoclonal antibody specifically binds to the human chemokine receptor, CCR5. CCR5 is also known as CD195. CCR5 is a seven transmembrane-spanning G protein-associated molecule. CCR5 belongs to the beta chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3+CD45RO+CD95+). CCR5 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation. It signals a response to at least three chemokines: Regulated upon Activation Normal T-cell Expressed and Secreted (RANTES), Macrophage Inflammatory Protein-1 (MIP-1) and Monocyte Chemoattractant Protein 2 (MCP-2). Additionally, CCR5 has been found to be a coreceptor for macrophage-tropic HIV-1 on CD4+ cells, a characteristic that is important in viral transmission. Reports indicate that individuals who have partial (heterozygous) or complete (homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV infection. This antibody has been shown to block ligand and gp120 binding. It is also able to neutralize HIV infection.

Spezifikation

Spezifikation

CD195
2D7/CCR5
CCR5; C-C chemokine receptor type 5; CC-CKR-5; CKR5; CHEMR13
Affinity Purified
Human CCR5 Transfected Cell Line
100 Tests
Immunology
Primary
Human
Flow Cytometry
PE-Cyanine7
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG2a, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.