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CD195 Mouse anti-Human, FITC, Clone: 2D7/CCR5, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 561747

Additional Details : Gewicht : 0.02000kg

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Artikelnummer. 15821299

  • 182.00 CHF / 1 Stück


Verfügbar ab
01-06-2021
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Beschreibung

Beschreibung

Reacts with the chemokine receptor, CCR5, a seven transmembrane-spanning G protein-associated molecule. CCR5 belongs to the β chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3+, CD45RO+, CD95+). CCR5 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation. It signals a response to at least three chemokines: RANTES and macrophage inflammatory protein-1 (MIP-1) α and β. Additionally, CCR5 has been found to be a co-receptor for macrophage-tropic HIV-1 on CD4+ cells, a characteristic that is important in viral transmission. Reports indicate that individuals who have partial (heterozygous) or complete (homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV infection. This antibody has been shown to block ligand and gp120 binding. It is also able to neutralize HIV infection. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: 2D7/CCR5
Isotype: IgG2a κ
Species Reactivity: Human

Flow Cytometry

Spezifikation

Spezifikation

CD195
2D7/CCR5
CCR5; C-C chemokine receptor type 5; CC-CKR-5; CKR5; CHEMR13
Affinity Purified
Human CCR5 Transfected Cell Line
25 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
FITC
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Murine
IgG2a, κ
RUO
Primary
Human
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.