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CD19 Rat anti-Mouse, V450, Clone: 1D3, BD

Rat Monoclonal Antibody

Marke:  BD Biosciences 560375

Additional Details : Gewicht : 0.10000kg

 Lernen Sie weitere Varianten dieses

Artikelnummer. 15830149

  • 335.00 CHF / 1 Stück


Verfügbar ab
27-05-2021
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

The 1D3 antibody reacts with CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 95kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to
play a role in complement-mediated mast-cell activation. The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is available exclusively from BD Biosciences. It is excited by the Violet laser Ex max of 406nm and has an Em Max at 450nm. Conjugates with
BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates.

Host Species: Rat
Clone: 1D3
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Mouse CD19 Transfected Cell Line

Flow Cytometry, Immunohistochemistry (Frozen), Intracellular Staining

Spezifikation

Spezifikation

CD19
1D3
V450
Affinity Purified
Mouse CD19 Transfected Cell Line
0.1mg
Immunology
Primary
Murine
Flow Cytometry
0.2mg/mL
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Rat
IgG2a, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.