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CD16 Mouse anti-Human, Alexa Fluor 647, Clone: 3G8, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 557710

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15819008

  • 413.00 CHF / 1 Stück


Verfügbar ab
27-05-2021
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Beschreibung

Beschreibung

The 3G8 monoclonal antibody specifically binds to the 50-65 kDa transmembrane form of the IgG Fc Receptor (FcγRIII), a human NK cell-associated antigen. CD16 is expressed on NK cells as well as macrophages and granulocytes. Reports indicate that CD16 plays a role in signal transduction and NK cell activation. The 3G8 antibody blocks the binding of soluble immune complexes to granulocytes. The 3G8 antibody is reported (Vossebeld et al., 1997) to increase intracellular calcium levels in human neutrophils by interacting with bothFcγRIIa and FcγRIIIb molecules. This antibody has also been reported to induce homotypic neutrophil aggregation.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Spezifikation

Spezifikation

CD16
3G8
FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3
Affinity Purified
Human polymorphonuclear leukocytes
100 Tests
Immunology
Primary
Baboon, Cynomolgus, Human, Rhesus
Flow Cytometry
Alexa Fluor 647
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.