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CD152 Hamster anti-Mouse, PE, Clone: UC10-4F10-11, BD

Hamster Monoclonal Antibody

Marke:  BD Biosciences 561718

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15831269

  • 136.00 CHF / 1 Stück


Verfügbar ab
01-06-2021
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

The UC10-4F10-11 antibody reacts with CD152 (CTLA-4), which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor. CTLA-4 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. Whereas CD28 delivers a costimulatory signal required for T-cell activation, CTLA-4 is a negative regulator of cell-mediated immune responses. CD152 may play roles in induction and/or maintenance of immunological tolerance, regulation of protective immunity, and autoimmune responses, and regulation of some aspects of thymocyte maturation. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.

Spezifikation

Spezifikation

CD152
UC10-4F10-11
PE
Aqueous buffered solution containing ≤0.09% sodium azide.
Hamster
IgG1, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
CTLA-4
Affinity Purified
Mouse CTLA-4 IgG2a Fusion
25μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.