CD152 Mouse anti-Human, APC, Clone: BNI3, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 560938
Additional Details : Gewicht : 0.01000kg
Reacts with the “cytolytic T lymphocyte-associated antigen”, CTLA-4. CTLA-4 is transiently expressed on activated CD28+ T cells and binds to CD80 and CD86 present on antigen presenting cells (APC) with high avidity. This interaction appears to deliver a negative regulatory signal to the T cell. There are recent reports that indicate that CTLA-4 is also expressed on B cells when cultured with activated T cells, suggesting a possible role of CTLA-4 in the regulation of B-cell response. Immobilized BNI3.1 enhances T-cell proliferation induced by CD3 and CD28. Recent studies have showed that CD152 can be expressed by regulatory T (Treg) cells. It has been found this antibody can stain the
intracellular CD152 on the Treg cells after fixation and permeabilization of cells.
Host Species: Mouse
Isotype: IgG2a κ
Species Reactivity: Human
Flow Cytometry, Intracellular Staining
|CTLA-4; AILIM; Cytotoxic T-lymphocyte protein 4|
|Human CTLA4 Recombinant Protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
For Research Use Only.