δ-Catenin Mouse, Unlabeled, Clone: 30, BD

Beschreibung

The catenins (α, β, γ, δ, p120[ctn]) are cytoplasmic proteins that are related to the Drosophila Armadillo protein. Catenins may have dual roles since they are components of cell-cell adherens junctions and can translocate to the nucleus after stimulation of the Wingless (Wnt-1 homolog) signaling pathway. α-Catenin has two subtypes: αE-Catenin, which is expressed ubiquitously, and αN-Catenin, which is expressed in the nervous system. β-Catenin binds to the cytoplasmic tail of E-Cadherin at adherens junctions and has been implicated in Wnt-1 signaling. γ-Catenin is associated with desmoglein in desmosomes and is closely related to β-Catenin. p120[ctn] is related to both β- and γ-catenin and is a substrate of tyrosine kinases localized at adherens junctions. δ-catenin was identified by its ability to bind the Alzheimer's disease-related protein, presenilin-1. It is most closely related to p120[ctn] and the desmosomal protein, p0071. It contains 10 Armadillo (Arm) repeats, as compared to the 13 Arm repeats found in β-Catenin. δ-Catenin is expressed at high levels in the developing nervous system, where it may be involved in neuronal progenitor cell migration and dendrite development.

Host Species: Mouse
Clone: 30
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse δ-Catenin aa. 85-194
Formula Weight [Chemical]: 160kDa

Immunofluorescence, Western Blotting