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Caspase-8 Mouse anti-Human, Unlabeled, Clone: 3-1-9, BD

Mouse Monoclonal Antibody

349.00 CHF - 679.00 CHF

Spezifikation

Antigen Caspase-8
Klon 3/1/2009
Konzentration 0.5mg/mL
Anwendungen Western Blot
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15816588
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BD Biosciences
551242
50 μg
349.00 CHF
1 Stück
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15826588
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BD Biosciences
551243
150 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
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Beschreibung

Beschreibung

Caspase-8 (FLICE/MACH-1) is a 55kDa cytosolic protein with homology to the CD95/Fas-associated signal transducer, FADD/MORT-1, as well as to other caspase (ICE/Ced-3) cysteine proteases. The N-terminal region of caspase-8 contains an amino acid sequence, termed the death domain, that facilitates caspase-8-FADD direct interaction. FADD therefore acts as an adapter molecule, allowing caspase-8 to become recruited to the cytoplasmic region of Fas following receptor activation. Viral proteins (v-FLIPS) which inhibit recruitment and activation of
caspase-8 have been isolated. Caspase-8 is produced as a proenzyme (55/50kDa doublet) which upon receptor aggregation is proteolytically cleaved into smaller subunits of 40/36 (doublet), and 23kDa. Overexpression of caspase-8 is sufficient to induce apoptosis in certain cell lines (e.g., MCF-7) and this phenotype is blocked by overexpression of the caspase-3 protease inhibitor, CrmA. The antibody recognizes both the proform of human caspase-8 (55/50kDa doublet) as well as the cleaved forms which migrate at 40/36 (doublet) and 23kDa in SDS/PAGE. It
also immunoprecipitates the full-length human caspase-8. Full-length recombinant human caspase-8 protein was used as immunogen.

Host Species: Mouse
Clone: 3-1-9
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human Caspase-8 full-length recombinant protein

Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

Caspase-8
0.5mg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG1 κ
Affinity Purified
FLICE, MACH-1, Mch5
3/1/2009
Western Blot
Unconjugated
RUO
Human
Human Caspase-8 full-length recombinant protein
Primary
Store undiluted at 4°C
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For Research Use Only.