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Calcineurin Mouse, Unlabeled, Clone: 29, BD
Mouse Monoclonal Antibody
370.00 CHF - 588.24 CHF
Spezifikation
| Antigen | Calcineurin |
|---|---|
| Klon | 29 |
| Konzentration | 250μg/mL |
| Anwendungen | Western Blot |
| Klassifikation | Monoclonal |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
15815369
|
BD Biosciences
610259 |
50 μg |
370.00 CHF
1 Set |
Verfügbar ab: 17-05-2024
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|
15825369
|
BD Biosciences
610260 |
150 μg |
Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11. |
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Beschreibung
Calcineurin is a Ca2+/calmodulin-dependent protein phosphatase. The active enzyme is a heterodimer of a large calmodulin-binding catalytic subunit A (61kDa) and a smaller Ca2+ binding subunit B (19kDa). Regions corresponding to the calmodulin-binding site, an autoinhibitory domain, and a putative subunit B binding site have been identified within the large subunit A. The activity of calcineurin is sensitive to immunosuppressants such as cyclosporin A (CsA) and tacrolimus (FK506). The study of FK506-mediated inhibition of nitric oxide formation has revealed that nitric oxide synthase (NOS) is a calcineurin substrate. Calcineurin dephosphorylates NOS and enhances its catalytic activity. Therefore, Calcineurin is an essential mediator for efficient T cell antigen receptor (TCR)-mediated T cell activation.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Spezifikation
| Calcineurin | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2a | |
| Affinity Purified |
| 29 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Chicken, Frog, Human, Mouse, Rat | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.