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c-Myc with control Mouse anti-Human, Unlabeled, Clone: 9E10., BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 551101
Additional Details : Gewicht : 0.02000kg
Beschreibung
The myc gene family contains at least seven closely related genes, c-myc, N-myc, L-myc, P-myc, R-myc, S-myc, and B-myc. C-myc plays a role in proliferation, transformation, and differentiation. It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas. Cellular localization has been described as nuclear and/or cytopasmic. C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region. It forms sequence-specific (CACGTG) DNA binding heterodimers with max, a helixloop-helix/leucine zipper protein. Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation. DNA binding of myc-max dimers results in a conformational change of the DNA and transcriptional activation. C-myc migrates at 62 kDa in SDS-PAGE. Clone 9E10 recognizes human c-myc. A synthetic peptide corresponding to a C-terminal epitope of the human c-myc protein (AEEQKLISEEDL) was used as an immunogen.
Spezifikation
c-Myc with control | |
Monoclonal | |
Unconjugated | |
Affinity Purified | |
RUO | |
Purified Mouse Anti-Human c-Myc (50μg); Jurkat Cell Lysate (50μg) | |
Store undiluted at -20°C. |
Western Blot | |
9E10. | |
Mouse | |
50 μg | |
Primary | |
Human | |
IgG1 |
For Research Use Only.