missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Btk (pY551) & Itk (pY511) Mouse anti-Human, Alexa Fluor 647, Clone: 24A/BTK (Y551), BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 558134
Dieser Artikel kann nicht zurückgegeben werden.
Rückgaberichtlinie anzeigen
Beschreibung
B ruton's t yrosine k inase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling. The activity of Btk is regulated by Src mediated phosphorylation of the kinase domain at tyrosine 551 (Y551). This event induces Btk kinase activity and subsequent autophosphorylation at Y223. Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate. γ1 (PLC γ1), a key regulator of calcium mobilization and extracellular signal-regulated kinase (ERK) activation. Itk is regulated by an activating transphosphorylation event in which Y511 in the kinase domain is phosphorylated by Lck.
The 24a/BTK (Y551) monoclonal antibody recognizes the Y551-phosphorylated form of human Btk and the Y511 phosphorylated form of human Itk.
Spezifikation
| Btk (pY551) & Itk (pY511) | |
| Monoclonal | |
| Alexa Fluor 647 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| 24A/BTK (Y551) | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Phosphorylated Human Btk Peptide | |
| 50 Tests | |
| Cell Biology | |
| Human | |
| IgG1 κ |
Berichtigung von Produktinhalten
Bitte geben Sie uns Ihr Feedback zu den Produktinhalten, indem Sie das folgende Formular ausfüllen.
Name des Produkts
Btk (pY551) & Itk (pY511) Mouse anti-Human, Alexa Fluor 647, Clone: 24A/BTK (Y551), BD > 50 Tests; Alexa Fluor 647
For Research Use Only.
Haben Sie Verbesserungsvorschläge?Übermitteln Sie eine inhaltliche Korrektur