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BLNK Mouse, Unlabeled, Clone: 2B11, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 559930
Artikelnummer. 15839828
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364.00 CHF
363.80 CHF / 1 Stück
Sparen 0.20 CHF
0.06% Rabatt
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Beschreibung
B cell activation is initiated by crosslinking the B cell receptor, which leads to activation of non-receptor protein tyrosine kinases (PTK), including Btk, Syk, and three Src kinases, Fyn, Lyn, and Blk. Activated PTKs then phosphorylate multiple cellular proteins involved in B lymphocyte signaling. Syk is responsible for the tyrosine phosphorylation of B cell l i nk er protein (BLNK), a member of the SLP-76 family of adapter proteins. Phosphorylation of human BLNK at tyrosines 84, 178, and 189 (Y84, Y178, and Y189) creates docking sites for PLC g
The 2B11 monoclonal antibody recognizes BLNK, regardless of phosphorylation status. A fusion protein representing amino acids 4-205 of human BLNK was used as the immunogen. BLNK is expressed as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE that represent alternatively spliced forms of human BLNK.
Spezifikation
| BLNK | |
| Monoclonal | |
| 0.5mg/mL | |
| SLP-65, BASH, BCA | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human, Mouse | |
| IgG2a κ |
| Western Blot | |
| 2B11 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Human N-terminal BLNK Recombinant Protein | |
| 0.1 mg | |
| Primary | |
| Store undiluted at 4°C |
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