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Amphiregulin Mouse anti-Human, APC, Clone: AREG559, eBioscience™

Mouse Monoclonal Antibody

Marke:  Invitrogen 17-5370-41

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15963214

  • 131.00 CHF / 25 Stück


Voraussichtliches Versanddatum: 28-09-2021
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Beschreibung

Beschreibung

Description: The AREG858 monoclonal antibody reacts with human Amphiregulin (AR). AR is a member of the Epidermal Growth Factor (EGF) family and is expressed as a transmembrane precursor protein and released by proteolytic cleavage. Soluble AR is a ligand for the EGF receptor (EGFR) and the interaction promotes growth of normal epithelial cells, fibroblasts and keratinocytes. In the context of the immune system AR functions as an effector molecule for tissue repair and homeostasis, mediates resistance and tolerance to infection, and suppresses inflammation. Under different disease and activating conditions AR is expressed in T cells, group 2 innate lymphoid cells, basophils, mast cells, eosinophils, and neutrophils. Applications Reported: This AREG559 antibody has been reported for use in flow cytometric analysis. Applications Tested: This AREG559 antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (Product No. 88-8824) and protocol. Please refer to Best Protocols: Protocol A: Two step protocol for (cytoplasmic) intracellular proteins located under the Resources Tab online. This may be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and beta cellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by six evenly spaced cysteine residues that generate three loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
Spezifikation

Spezifikation

Amphiregulin
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P15514
Colorectum cell-derived growth factor, CRDGF, AREG, SDGF, Mcub, AREGB, MGC13647
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
AREG559
APC
AREG
Liquid
AREG
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
374
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate