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Invitrogen™ Amphiphysin Polyclonal Antibody
Rabbit Polyclonal Antibody
Marke: Invitrogen™ PA521483
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Beschreibung
Recommended positive controls: mouse hippocampus, mouse brain, rat brain. Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (91%), Pig (100%), Chicken (95%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.
Spezifikation
| Amphiphysin | |
| Polyclonal | |
| Unconjugated | |
| Amph | |
| Amph; AMPH1; amphiphysin; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); amphiphysin 1; amphiphysin I; HGNC:471 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 218038, 273, 60668 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.9 mg/mL | |
| 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
| O08838, P49418, Q7TQF7 | |
| Amph | |
| Recombinant protein encompassing a sequence within the N-terminus region of human Amphiphysin. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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