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Amiloride hydrochloride dihydrate

Artikelnummer. 15424599
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Artikelnummer. 15424599 Lieferant Thermo Scientific Alfa Aesar Lieferanten-Nr. J62168.06
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Beschreibung

Sodium channel blocker | CAS: 17440-83-4 | C6H13Cl2N7O3 | 302.116 g/mol

Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride

  • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Solubility
Soluble in water at 50mg/ml

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 17440-83-4
Summenformel C6H13Cl2N7O3
Molekulargewicht (g/mol) 302.116
MDL-Nummer MFCD00058197
InChI-Schlüssel LTKVFMLMEYCWMK-UHFFFAOYSA-N
Synonym amiloride hydrochloride dihydrate, modamide, nirulid, amiloride hcl, amiloride hcl dihydrate, amilorid hydrochlorid-2-wasser, unii-fzj37245uc, amiloride hydrochloride usan:usp, amiloride dihydrate hydrochloride, n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate
PubChem CID 68540
ChEBI CHEBI:2640
IUPAC-Name 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
SMILES C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl

Spezifikation

Chemischer Name oder Material Amiloride hydrochloride dihydrate
Schmelzpunkt >240°C
Farbe Gelb
Menge 5 g
UN-Nummer UN2811
Merck Index 14,406
Löslichkeitsinformationen Soluble in water at 50mg/ml
Formelmasse 266.09
Physikalische Form Pulver

RUO – Research Use Only

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