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![Human ACVR1 [R206H], GST Tag Recombinant Protein 10μg](https://assets.fishersci.com/TFS-Assets/LSG/product-images/Cell_Bio_Rec_Prot_Invitrogen_Vial.jpg-650.jpg)
Human ACVR1 [R206H], GST Tag Recombinant Protein
Human ACVR1 [R206H], GST Tag Recombinant Protein
Marke: Invitrogen PV6232
Additional Details : Gewicht : 0.01000kg
Beschreibung
ACVR1 signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 are associated with fibrodysplasia ossificans progressiva (FOP) and the mutations are located in or adjacent to the GS regulatory region or active site of the kinase. The mutations in ACVR1 were predicted by protein structure homology modeling to activate the ACVR1 protein and enhance receptor signaling. Dysregulated ACVR1 kinase activity plays a role in the pathogenesis of FOP.
- Validated in LanthaScreen™ Kinase Binding Assay
- Protocols available for simple use and optimized performance
- Multiple pack sizes available for convenient use
Spezifikation
| 67.6 kDa | |
| ACVR1, FOP, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2 | |
| Human | |
| GST Tag | |
| Biochemical binding/kinetic | |
| ACVR1 (ALK2) R206H | |
| Recombinant |
| 10μg | |
| aa 147-end | |
| Recombinant | |
| Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. |
|
| Serine/Threonine Kinase | |
| Baculovirus |