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Rapamycin, 99+%, Thermo Scientific™
Rapamycin, CAS # 53123-88-9, is a macrolide compound showing suppressor activity against the immune system and also exhibits inhibitory activity in tumor growth.
Marke: Thermo Scientific Alfa Aesar J62473.MF
| Menge | 50mg |
|---|
Artikelnummer. 15444849
-
187.07 CHF / 50 Milligramm
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This item is not returnable.
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Description
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
- Rapamycin is a natural macrolide compound showing antiproliferative activities in mammalian cells
- Rapamycin is a specific inhibitor of rapamycin kinase. It forms a complex with FKBP12 that consequently binds and inhibits rapamycin’s molecular target (rapamycin kinase)
Application
- Rapamycin inhibits tumor growth by preventing tumor cell proliferation and suppressing tumor angiogenesis
- This compound also blocks cytokine-mediated signal transduction pathways
- Rapamycin also promotes the suppression of the immune system
- It was initially defined as an antifungal metabolite produced by Streptomyces hygroscopicus
- In vitro studies demonstrated that this compound is an important mediator of PI3 kinase signaling
Specifications
| Rapamycin | |
| White | |
| C51H79NO13 | |
| 14,8114 | |
| Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol,dimethyl sulfoxide and dimethyl formamide; Insoluble in water. | |
| CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC | |
| 5284616 | |
| 914.17 |
| 53123-88-9 | |
| 50mg | |
| MFCD00867594 | |
| Sirolimus; AY-22989 | |
| QFJCIRLUMZQUOT-HPLJOQBZSA-N | |
| 914.187 | |
| CHEBI:9168 | |
| ≥99% |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- Rapamycin
Signal Word
- Gefahr
Hazard Category
- Karzinogenität Kategorie 2
- Reproduktionstoxizität Kategorie 2
- Spezifische Zielorgan-Toxizität Kategorie 1
Hazard Statement
- H351-Kann vermutlich Krebs erzeugen.
- H361-Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen.
- H372-Schädigt die Organe.
Precautionary Statement
- P201-Vor Gebrauch besondere Anweisungen einholen.
- P280-Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.
- P308+P313-BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
Supplemental information
- MIXTURE LIST-Enthält: Sirolimus
Product Title
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