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  7. 6(5H)-phenanthridinon, 96 %, Thermo Scientific Chemicals

6(5H)-phenanthridinon, 96 %, Thermo Scientific Chemicals

Product Code. 11470648
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Product Code. 11470648 Supplier Thermo Scientific Alfa Aesar Supplier No. B25187.06
 Eingeschränkter Artikel
Verfügbar ab: 30-09-2026
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Description

CAS: 1015-89-0 | C13H9NO | 195.221 g/mol

6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Anwendungen
6(5 H)-Phenanthridinon wird als Sonde zur Rolle von PARP bei der zellulären Reaktion auf Bestrahlung verwendet. Die Behandlung von Zellen mit 6(5H)-Phenanthridinon und verschiedenen DNA-schädlichen Wirkstoffen zeigte eine Resistenz gegen Apoptose. Es wirkt als Reaktionsmittel bei der Synthese von 5,6-Dihydrophenanthridinsulfonamiden, der oxidativen Kopplung mit Diphenylacetylen und der direkten Kupferacetat-katalysierten N-Cyclopropylierung zyklischer Amide. Es wird als HIV-1Integrase-Inhibitor eingesetzt.

Löslichkeit
Löslich in DMSO (5 mg/ml). Unlöslich in Wasser.

Hinweise
Inkompatible Materialien sind Oxidationsmittel. Kühl lagern. Behälter an einem trockenen und gut belüfteten Ort dicht verschlossen halten.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1015-89-0
Summenformel C13H9NO
Molekulargewicht (g/mol) 195.221
MDL-Nummer MFCD00004988
InChI-Schlüssel RZFVLEJOHSLEFR-UHFFFAOYSA-N
Synonym 6 5h-phenanthridinone, phenanthridin-6 5h-one, 6-phenanthridinol, phenanthridone, 6-5h-phenanthridinone, 6-phenanthridone, 6-phenanthridinone, 6 5h-phenanthridone, phenanthridin-6-ol, phenantridone
PubChem CID 1853
ChEBI CHEBI:75292
IUPAC-Name 5H-Phenanthridin-6-on
SMILES C1=CC=C2C(=C1)C3=CC=CC=C3NC2=O

Specifications

Chemischer Name oder Material 6(5H)-Phenanthridinone
Schmelzpunkt 288°C to 294°C
Menge 5 g
Beilstein 140641
Löslichkeitsinformationen Soluble in DMSO (5mg/ml). Insoluble in water.
Formelmasse 195.22
Reinheit (%) 96%

RUO – Research Use Only

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