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4-Nitrobenzolsulfonylchlorid, 97 %, Thermo Scientific Chemicals

Product Code. 11418427
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Description

CAS: 98-74-8 | C6H4ClNO4S | 221.61 g/mol

4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Anwendungen
4-Nitrobenzolsulfonylchlorid wird als Zwischenprodukt für die Synthese von Pharmazeutika wie Fosamprenavir, Darunavir und Amprenavir verwendet. Es ist an der Herstellung von N-Nosyl-alpha-Aminosäure für die Peptidsynthese beteiligt. Es wird auch für die stereoselektive α-Glukosylierung von teilgeschützten Kohlenhydraten in Verbindung mit Silbertrifluormethansulfonat, N,N-Dimethylacetamid und Triethylamin verwendet. Es wird häufig für die Synthese von Hydroxylaminen von Sulfadiazin, Sulfamethoxazol und [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-Bipyridin, nbs = 4-Nitrobenzolsulfonat) verwendet.

Löslichkeit
Löslich in Toluol, Tetrahydrofuran, Methylenchlorid und Ethylacetat. Nicht in Wasser löslich.

Hinweise
Feuchtigkeitsempfindlich. Nicht kompatibel mit starken Oxidationsmitteln und starken Basen.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 98-74-8
Summenformel C6H4ClNO4S
Molekulargewicht (g/mol) 221.61
MDL-Nummer MFCD00007445
InChI-Schlüssel JXRGUPLJCCDGKG-UHFFFAOYSA-N
Synonym 4-nitrobenzenesulfonylchloride, 4-nitrobenzene-1-sulfonyl chloride, benzenesulfonyl chloride, 4-nitro, 4-nitrobenzenesulphonyl chloride, 4-nitrophenylsulfonyl chloride, p-nitrophenylsulfonyl chloride, 4-nitrobenzenesulfonic acid chloride, p-nitrobenzenesulfonyl chloride, 4-nitrobenzenesulphonylchloride, 4-nitro-benzenesulfonyl chloride
PubChem CID 7404
SMILES [O-][N+](=O)C1=CC=C(C=C1)S(Cl)(=O)=O

Specifications

Chemischer Name oder Material 4-Nitrobenzenesulfonyl chloride
Schmelzpunkt 76°C to 80°C
Siedepunkt 143°C to 144°C (1.5 mmHg)
Menge 25 g
UN-Nummer UN3261
Beilstein 746543
Empfindlichkeit Moisture sensitive
Löslichkeitsinformationen Soluble in toluene,tetrahydrofuran,methylene chloride and ethyl acetate. Insoluble in water.
IUPAC-Name 4-Nitrobenzolsulfonylchlorid
Formelmasse 221.62
Reinheit (%) 97%
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