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  6. 17-(Allylamino)-17-Demethoxygeldanamycin, 99 %, Thermo Scientific Chemicals

17-(Allylamino)-17-Demethoxygeldanamycin, 99 %, Thermo Scientific Chemicals

Artikelnummer. 15438539
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Artikelnummer. 15438539 Lieferant Thermo Scientific Alfa Aesar Lieferanten-Nr. J66960.MC
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Beschreibung

Zeigt Anti-Tumor-Aktivität

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Löslichkeit
Löslich in DMSO bei 150 mg/ml; löslich in Ethanol bei 5 mg/ml. Sehr schlecht wasserlöslich

Hinweise
Nur für Forschungszwecke: Nicht für diagnostische oder therapeutische Zwecke an Tieren und Menschen geeignet.
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 75747-14-7
Summenformel C31H43N3O8
Molekulargewicht (g/mol) 585.698
MDL-Nummer MFCD04973892
InChI-Schlüssel AYUNIORJHRXIBJ-MKJFUHJFSA-N
Synonym 17-aag
PubChem CID 133688938
IUPAC-Name [(3S,5R,6S,7R,8Z,11R,14E)-6-Hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamat
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

Specifica

Chemischer Name oder Material 17-(Allylamino)-17-demethoxygeldanamycin
Schmelzpunkt 207°C to 209°C
Flammpunkt >110°C (230°F)
Menge 100 mg
Empfindlichkeit Lichtempfindlich
Löslichkeitsinformationen Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/ml; Very poorly soluble in water
Formelmasse 585.69
Reinheit (%) 99%
Physikalische Form Fest

RUO – Research Use Only

Titolo del prodotto
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