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SC 514, Tocris Bioscience™
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Menge:
10 mg
50 mg
Beschreibung
Orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF-κB-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC50 values are 20, 20 and 8 μM respectively). Reduces iNOS induction and exhibits anti-inflammatory activity in vivo.
Spezifikation
Chemischer Name oder Material | SC 514 |
Menge | 10 mg |
Formelmasse | 224.3 |
Reinheit (%) | >98% |
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