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  7. NBI 35965 hydrochloride, Tocris Bioscience™

NBI 35965 hydrochloride, Tocris Bioscience™

Catalog Number 18075422
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Menge:
10 mg
50 mg
Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen
603151-83-3
C21H23Cl3N4
437.793
LNYUWBPFYXPUIO-RSAXXLAASA-N
nbi 35965 hydrochloride, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-4-methyl-7,8-dihydro-6h-1,3,6,8a-tetraazaacenaphthylene-hydrogen chloride 1/1, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-7,8-dihydro-4-methyl-6h-1,3,6,8a-tetraazaacenaphthylene hydrochloride
71433630
CCC1CN2C3=C(C(=N2)C4=C(C=C(C=C4)Cl)Cl)N=C(C=C3N1CC5CC5)C.Cl
Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen
603151-83-3
C21H23Cl3N4
437.793
LNYUWBPFYXPUIO-RSAXXLAASA-N
nbi 35965 hydrochloride, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-4-methyl-7,8-dihydro-6h-1,3,6,8a-tetraazaacenaphthylene-hydrogen chloride 1/1, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-7,8-dihydro-4-methyl-6h-1,3,6,8a-tetraazaacenaphthylene hydrochloride
71433630
CCC1CN2C3=C(C(=N2)C4=C(C=C(C=C4)Cl)Cl)N=C(C=C3N1CC5CC5)C.Cl

Beschreibung

Potent and selective CRF1 antagonist

Potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki values are 4 and > 10000 nM at CRF1 and CRF2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.
Chemischer Name oder Material NBI 35965 hydrochloride
Menge 10 mg
Formelmasse 437.79
Reinheit (%) >98%
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