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LE 135, Tocris Bioscience™
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50mg
Beschreibung
Retinoic acid antagonist; displays moderate selectivity for RARβ over RARα (Ki values are 0.22 and 1.4 μM respectively). Highly selective over RARγ and RXRα. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50 = 150 nM).
Spezifikation
Chemischer Name oder Material | LE 135 |
CAS | 155877-83-1 |
Summenformel | C29H30N2O2 |
Menge | 50 mg |
Synonym | chembl37708, 4-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5h-benzo e naphtho 2,3-b 1,4 diazepin-13-yl benzoic acid, d0x5wp, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5h-5,12-diaza-benzo 4,5 cyclohepta 1,2-b naphthalen-13-yl-benzoic acid, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5h-benzo e naphtho 2,3-b 1,4 diazepin-13-yl benzoic acid, 4-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho 2,3-b 1, 4 benzodiazepin-13-yl benzoic acid, 4-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho 2,3-b 1,4 benzodiazepin-13-yl benzoic acid |
InChI-Schlüssel | YZZAIQOVMHVWBS-UHFFFAOYSA-N |
SMILES | CC1(CCC(C2=CC3=C(C=C21)N=C(C4=CC=CC=C4N3C)C5=CC=C(C=C5)C(=O)O)(C)C)C |
IUPAC-Name | 4-(5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,4]benzodiazepin-13-yl)benzoic acid |
Molekulargewicht (g/mol) | 438.571 |
PubChem CID | 10410894 |
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